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原著論文

2023

[1] A Facile Method to Coat Nanoparticles with Lipid Bilayer Membrane: Hybrid Silica Nanoparticles Disguised as Biomembrane Vesicles by Particle Penetration of Concentrated Lipid Layers
R. Mizuta; F. Inoue; Y. Sasaki; S. Sawada; K. Akiyoshi
Small, 19, 2206153, 2023
DOI: 10.1002/smll.202206153

2022

[19] Classification of Extracellular Vesicles Based on Surface Glycan Structures by Spongy-like Separation Media
E. Kanao; S. Wada; H. Nishida; T. Kubo; T. Tanigawa; K. Imami; A. Shimoda; K. Umezaki; Y. Sasaki; K. Akiyoshi; J. Adachi; K. Otsuka; Y. Ishihama
Anal. Chem., 94, 51, 18025 - 18033, 2022
DOI: 10.1021/acs.analchem.2c04391

[18] Extraction and Biological Evaluation of Matrix-Bound Nanovesicles (MBVs) from High-Hydrostatic Pressure-Decellularized Tissues
M. Kobayashi; N. Ishida; Y. Hashimoto; J. Negishi; H. Saga; Y. Sasaki; K. Akiyoshi; T. Kimura; A. Kishida
Int. J. Mol. Sci., 23, 16, 8868, 2022
DOI: 10.3390/ijms23168868

[17] Three-Dimensional Culture of Cartilage Tissue on Nanogel-Cross-Linked Porous Freeze-Dried Gel Scaffold for Regenerative Cartilage Therapy: A Vibrational Spectroscopy Evaluation
T. Adachi; N. Miyamoto; H. Imamura; T. Yamamoto; E. Marin; W. Zhu; M. Kobara; Y. Sowa; Y. Tahara; N. Kanamura; K. Akiyoshi; O. Mazda; I. Nishimura; G. Pezzotti
Int. J. Mol. Sci., 23, 15, 8099, 2022
DOI: 10.3390/ijms23158099

[16] Perforated Hydrogels Consisting of Cholesterol-Bearing Pullulan (CHP) Nanogels: A Newly Designed Scaffold for Bone Regeneration Induced by RANKL-Binding Peptides and BMP-2
CY. Xie; M. Satake-Ozawa; F. Rashed; M. Khan; M. Ikeda; S. Hayashi; S. Sawada; Y. Sasaki; T. Ikeda; Y. Mori; K. Akiyoshi; K. Aoki
Int. J. Mol. Sci., 23, 14, 7768, 2022
DOI: 10.3390/ijms23147768

[15] Induction of Mucosal IgA-Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel-Based P6 Nasal Vaccine
R. Nakahashi-Ouchida; H. Mori; Y. Yuki; S. Umemoto; T. Hirano; Y. Uchida; T. Machita; T. Yamanoue; S. Sawada; M. Suzuki; K. Fujihashi; K. Akiyoshi; Y. Kurono; H. Kiyono
Front. Immunol., 13, 819859, 2022
DOI: 10.3389/fimmu.2022.819859

[14] Glycopeptoid Nanospheres: Glycosylation-Induced Coacervation of Poly(sarcosine)
Y. Okuno; T. Nishimura; Y. Sasaki; K. Akiyoshi
Nanoscale Adv., 4, 3707 - 3710, 2022
DOI: 10.1039/D2NA00218C

[13] Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N-isopropylacrylamide)s in Water
N. Morimoto; F. Segui; X.P. Qiu; K. Akiyoshi; F.M. Winnik
Langmuir, 38, 17, 5218 - 5225, 2022
DOI: 10.1021/acs.langmuir.1c02394

[12] Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance
D. Muraoka; N. Harada; H. Shiku; K. Akiyoshi
Journal of Controlled Release, 347, 175 - 182, 2022
DOI: 10.1016/j.jconrel.2022.05.004

[11] Immunological response of polysaccharide nanogel-incorporating PEG hydrogels in an in vivo diabetic model
T. Bal; I.C. Karaoglu; F.S. Murat; E. Yalcin; Y. Sasaki; K. Akiyoshi; S. Kiziel
J. Biomater. Sci. Polym. Ed., 2022
DOI: 10.1080/09205063.2022.2077512

[10] Fusogenic Hybrid Extracellular Vesicles with PD-1 Membrane Proteins for the Cytosolic Delivery of Cargos
R. Ishikawa; S. Yoshida; S. Sawada; Y. Sasaki; K. Akiyoshi
Cancers, 14, 11, 2635, 2022
DOI: 10.3390/cancers14112635

[9] Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain
T. Nishimura; Y. Hatatani; M. Ando; Y. Sasaki; K. Akiyoshi
Chem. Sci., 13, 5243 - 5251, 2022
DOI: 10.1039/D2SC01674E

[8] Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
R. Kawasaki; K. Kondo; R. Miura; K. Yamana; H. Isozaki; R. Shimada; S. Kawamura; H. Hirano; T. Nishimura; N. Tarutani; K. Katagiri; A. Stubelius; S. Sawada; Y. Sasaki; K. Akiyoshi; A. Ikeda
Int. J. Mol. Sci., 23, 9, 4686, 2022
DOI: 10.3390/ijms23094686

[7] CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma
H. Odaka; K. Hiemori; A. Shimoda; K. Akiyoshi; H. Tateno
BMC Gastroenterology, 22, 153, 2022
DOI: 10.1186/s12876-022-02228-7

[6] Development and single-particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins
R. Ishikawa; S. Yoshida; S. Sawada; Y. Sasaki; K. Akiyoshi
FEBS Open Bio, 12, 6, 1178 - 1187, 2022
DOI: 10.1002/2211-5463.13406

[5] Reversible conjugation of biomembrane vesicles with magnetic nanoparticles using a self-assembled nanogel interface: single particle analysis using imaging flow cytometry
R. Mizuta; Y. Sasaki; K. Katagiri; S. Sawada; K. Akiyoshi
Nanoscale Adv., 4, 1999 - 2010, 2022
DOI: 10.1039/D1NA00834J

[4] Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method
N. Seo; J. Nakamura; T. Kaneda; H. Tateno; A. Shimoda; T. Ichiki; K. Furukawa; J. Hirabayashi; K. Akiyoshi; H. Shiku
J. Extracell. Vesicles, 11, 3, e12205, 2022
DOI: 10.1002/jev2.12205

[3] A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect
Y. Tahara; R. Mizuno; T. Nishimura; S. Mukai; R. Wakabayashi; N. Kamiya; K. Akiyoshi; M. Goto
Biomaterials, 282, 121385, 2022
DOI: 10.1016/j.biomaterials.2022.121385

[2] Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications
A. Shimoda; R. Miura; H. Tateno; N. Seo; H. Shiku; S. Sawada; Y. Sasaki; K. Akiyoshi
Small Methods, 6, 2, 2100785, 2022
DOI: 10.1002/smtd.202100785

[1] Embedding a membrane protein into an enveloped artificial viral replica
H. Furukawa; H. Inaba; Y. Sasaki; K. Akiyoshi; K. Matsuura
RSC Chem. Biol., 3, 231 - 241, 2022
DOI: 10.1039/D1CB00166C

2021

[13] Protein antigen conjugated with cholesteryl amino-pullulan nanogel shows delayed degradation in dendritic cells and augmented immunogenicity
W. Long; S. Kunitake; S. Sawada; K. Akiyoshi; T. Tsubata
Vaccine, 39, 52, 7526 - 7530, 2021
DOI: 10.1016/j.vaccine.2021.11.047

[12] Study on magnetic thermal seeds coated with thermal-responsive molecularly imprinted polymers
T. Kubo; M. Shimonaka; Y. Watabe; K. Akiyoshi; J. Balachandran; K. Otsuka
Nanocomposites, 7, 1, 215 - 225, 2021
DOI: 10.1080/20550324.2021.2008206

[11] Construction of Hybrid Cell Spheroids Using Cell-Sized Cross-Linked Nanogel Microspheres as an Artificial Extracellular Matrix
S. Hayashi; Y. Sasaki; H. Kubo; S. Sawada; N. Kinoshita; E. Marukawa; H. Harada; K. Akiyoshi
ACS Appl. Bio Mater., 4, 11, 7848 - 7855, 2021
DOI: 10.1021/acsabm.1c00796

[10] Osteogenic Response to Polysaccharide Nanogel Sheets of Human Fibroblasts After Conversion Into Functional Osteoblasts by Direct Phenotypic Cell Reprogramming
K. Nakai; K. Yamamoto; T. Kishida; S. Kotani; Y. Sato; S. Horiguchi; H. Yamanobe; T. Adachi; F. Boschetto; E. Marin; W. Zhu; K. Akiyoshi; T. Yamamoto; N. Kanamura; G. Pezzotti; O. Mazda
Front. Bioeng. Biotechnol., 9, 713932, 2021
DOI: 10.3389/fbioe.2021.713932

[9] Thermoresponsive Carbohydrate-b-Polypeptoid Polymer Vesicles with Selective Solute Permeability and Permeable Factors for Solutes
Y. Okuno; T. Nishimura; Y. Sasaki; K. Akiyoshi
Biomacromolecules, 22, 7, 3099 - 3106, 2021
DOI: 10.1021/acs.biomac.1c00530

[8] Manipulating the Morphology of Amphiphilic Graft-Copolymer Assemblies by Adjusting the Flexibility of the Main Chain
T. Nishimura; S. Fujii; K. Sakurai; Y. Sasaki; K. Akiyoshi
Macromolecules, 54, 14, 7003 - 7009, 2021
DOI: 10.1021/acs.macromol.1c01030

[7] A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci
R. Nakahashi-Ouchida; Y. Uchida; Y. Yuki; Y. Katakai; T. Yamanoue; H. Ogawa; Y. Munesue; N. Nakano; K. Hanari; T. Miyazaki; Y. Saito; S. Umemoto; S. Sawada; R. Mukerji; D. E. Briles; Y. Yasutomi; K. Akiyoshi; H. Kiyono
Vaccine, 39, 25, 3353 - 3364, 2021
DOI: 10.1016/j.vaccine.2021.04.069

[6] Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System
Y. Yuki; Y. Uchida; S. Sawada; R. Nakahashi-Ouchida; K. Sugiura; H. Mori; T. Yamanoue; T. Machita; A. Honma; S. Kurokawa; R. Mukerji; D. E. Briles; K. Akiyoshi; H. Kiyono
Mol. Pharmaceutics, 18, 4, 1582 - 1592, 2021
DOI: 10.1021/acs.molpharmaceut.0c01003

[5] Thermoresponsive glycopolymer vesicles: in situ observation of morphological changes and triggered cargo release
T. Nishimura; Y. Sasaki; K. Akiyoshi
Polymer Journal, 53, 1251 - 1258, 2021
DOI: 10.1038/s41428-021-00488-w

[4] Platelet‐derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4‐based assays
H. Odaka; K. Hiemori; A. Shimoda; K. Akiyoshi; H. Tateno
FEBS Open Bio., 11, 3, 741 - 752, 2021
DOI: 10.1002/2211-5463.13068

[3] New Lipophilic Fluorescent Dyes for Labeling Extracellular Vesicles: Characterization and Monitoring of Cellular Uptake
T. Shimomura; R. Seino; K. Umezaki; A. Shimoda; T. Ezoe; M. Ishiyama; K. Akiyoshi
Bioconjugate Chemistry, 32, 4, 680 - 684, 2021
DOI: 10.1021/acs.bioconjchem.1c00068

[2] Magnetically Navigated Protein Transduction In Vivo using Iron Oxide‐Nanogel Chaperone Hybrid
R. Kawasaki; Y. Sasaki; T. Nishimura; K. Katagiri; K. Morita; Y. Sekine; S. Sawada; S. Mukai; K. Akiyoshi
Adv. Healthcare Mater., 10, 9, 2001988, 2021
DOI: 10.1002/adhm.202001988

[1] Design and function of smart biomembrane nanohybrids for biomedical applications: review
Y. Sasaki; K. Akiyoshi
Polymer Journal, 53, 587 - 592, 2021
DOI: 10.1038/s41428-020-00453-z

2020

[15] Development of Lectin-immobilized Spongy Monoliths for Sub-classification of Exosome
T. Kubo; S. Kato; A. Shimoda; R. Ishikawa; S. Sawada; Y. Sasaki; K. Akiyoshi; K. Otsuka
BUNSEKI KAGAKU, 69, 12, 731 - 735, 2020
DOI: 10.2116/bunsekikagaku.69.731

[14] Identification of a dominant CD8⁺ CTL epitope in the SARS-associated coronavirus 2 spike protein
D. Muraoka; D. Situo; S. Sawada; K. Akiyoshi; N. Harada; H. Ikeda
Vaccine, 38, 49, 7697 - 7701, 2020
DOI: 10.1016/j.vaccine.2020.10.039

[13] In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging
T. Adachi; F. Boschetto; N. Miyamoto; T. Yamamoto; E. Marin; W. Zhu; N. Kanamura; Y. Tahara; K. Akiyoshi; O. Mazda; I. Nishimura; G. Pezzotti
Materials, 13, 19, 4275, 2020
DOI: 10.3390/ma13194275

[12] Biocatalytic Hybrid Films Self-Assembled from Carbohydrate Block Copolymers and Polysaccharides for Enzyme Prodrug Therapy
T. Nishimura; Y. Nakamura; N. Kinoshita; K. Yamamoto; Y. Sasaki; K. Akiyoshi
ACS Appl. Bio Mater., 3, 12, 8865 - 8871, 2020
DOI: 10.1021/acsabm.0c01174

[11] Determining the Hydration in the Hydrophobic Layer of Permeable Polymer Vesicles by Neutron Scattering
T. Nishimura; L. De Campo; H. Iwase; K. Akiyoshi
Macromolecules, 53, 17, 7546 - 7551, 2020
DOI: 10.1021/acs.macromol.0c01261

[10] Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes
M. Ando; Y. Sasaki; K. Akiyoshi
RSC Advances, 10, 28741 - 28745, 2020
DOI: 10.1039/D0RA05825D

[9] Thermoresponsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory
T. Nishimura; S. Shishi; Y. Sasaki; K. Akiyoshi
J. Am. Chem. Soc., 142, 27, 11784 - 11790, 2020
DOI: 10.1021/jacs.0c02290

[8] Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules
T. Nishimura; K. Akiyoshi
Bioconjugate Chemistry, 31, 5, 1259 - 1267, 2020
DOI: 10.1021/acs.bioconjchem.0c00133

[7] Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer
H. Furukawa; H. Inaba; F. Inoue; Y. Sasaki; K. Akiyoshi; K. Matsuura
Chem. Commun., 56, 7092 - 7095, 2020
DOI: 10.1039/D0CC02622K

[6] Crosslinked nanogel-based porous hydrogel as a functional scaffold for tongue muscle regeneration
N. Kinoshita; Y. Sasaki; E. Marukawa; R. Hirose; S. Sawada; H. Harada; K. Akiyoshi
J. Biomater. Sci. Polym. Ed., 31, 10, 1254 - 1271, 2020
DOI: 10.1080/09205063.2020.1744246

[5] Preparation of engineered extracellular vesicles with full-length functional PD-1 membrane proteins by baculovirus expression system
R. Ishikawa; S. Yoshida; S. Sawada; Y. Sasaki; K. Akiyoshi
Biochem. Biophys. Res. Commun., 526, 967 - 972, 2020
DOI: 10.1016/j.bbrc.2020.03.187

[4] Synergistic anti-tumor efficacy by combination therapy of a self-assembled nanogel vaccine with an immune checkpoint anti-PD-1 antibody
R. Miura; S. Sawada; S. Mukai; Y. Sasaki; K. Akiyoshi
RSC Advances, 10, 8074 - 8079, 2020
DOI: 10.1039/c9ra10066k

[3] Nanogel hybrid assembly for exosome intracellular delivery: Effects to endocytosis and fusion by exosome surface polymer engineering
S. Sawada; Y. T. Sato; R. Kawasaki; J. Yasuoka; R. Mizuta; Y. Sasaki; K. Akiyoshi
Biomater. Sci., 8, 619 - 630, 2020
DOI: 10.1039/c9bm01232j

[2] Substrate-sorting Nanoreactors based on Permeable Peptide Polymer Vesicles and Hybrid Liposomes with Synthetic Macromolecular Channels
T. Nishimura; S. Hirose; Y. Sasaki; K. Akiyoshi
J. Am. Chem. Soc., 142, 1, 154 - 161, 2020
DOI: 10.1021/jacs.9b08598

 

[1] Antigen delivery to antigen presenting cells for adaptive immune response by self-assembled anionic polysaccharide nanogel vaccines
R. Miura; S. Sawada; S. Mukai; Y. Sasaki; K. Akiyoshi
Biomacromolecules, 21, 2, 621 - 629, 2020
DOI: 10.1021/acs.biomac.9b01351

2019

[10] Supramacromolecular Injectable Hydrogels by Crystallization-driven Self-assembly of Carbohydrate-conjugated Poly(2-isopropyloxazoline)s for Biomedical Applications
T. Nishimura; N. Sumi; S. Mukai; Y. Sasaki; K. Akiyoshi
J. Mater. Chem. B, 7, 6362 - 6369, 2019
DOI: 10.1039/c9tb00918c

[9] Staphylococcus aureus-specific IgA antibody in milk suppresses the multiplication of S. aureus in infected bovine udder
Y. Nagasawa; Y. Kiku; K. Sugawara; A. Hirose; C. Kai; N. Kitano; T. Takahashi; T. Nochi; H. Aso; S. Sawada; K. Akiyoshi; T. Hayashi
BMC Veterinary Research, 15, 286, 2019
DOI: 10.1186/s12917-019-2025-3

[8] Magnetically navigated intracellular delivery of extracellular vesicles using amphiphilic nanogels
R. Mizuta; Y. Sasaki; R. Kawasaki; K. Katagiri; S. Sawada; S. Mukai; K. Akiyoshi
Bioconjugate Chemistry, 30, 2150 - 2155, 2019
DOI: 10.1021/acs.bioconjchem.9b00369

[7] Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array system
A. Shimoda; S. Sawada; Y. Sasaki; K. Akiyoshi
Scientific Reports, 9, 11497, 2019
DOI: 10.1038/s41598-019-47760-x

[6] Osteogenic response of mesenchymal progenitor cells to natural polysaccharide nanogel and atelocollagen scaffolds: A spectroscopic study
S. Horiguchi; T. Adachia; A. Rondinellac; F. Boschettob; E. Marina; W. Zhuc; Y. Tahara; T. Yamamoto; N. Kanamura; K. Akiyoshi; G. Pezzottib; O. Mazdab
Materials Science and Engineering: C, 99, 1325 - 1340, 2019
DOI: 10.1016/j.msec.2019.02.043

[5] Amphiphilic Poly[poly(ethylene glycol) methacrylate]s with OH Groups in the PEG Side Chains for Controlling Solution/Rheological Properties and toward Bioapplication
Y. Koda; D. Takahashi; Y. Sasaki; K. Akiyoshi
ACS Applied Bio Materials, 2, 1920 - 1930, 2019
DOI: 10.1021/acsabm.8b00836

[4] Nanogelation and Thermal Stabilization of Enzyme by Vitamin B6‑Bearing Polysaccharide as Biocrosslinker
Y. Sasaki; Y. Tsuchido; T. Yoshimura; K. Akiyoshi
ACS Biomaterials Science & Engineering, 5, 5752 - 5758, 2019
DOI: 10.1021/acsbiomaterials.9b00026

[3] Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery
S. Takeda; T. Nishimura; K. Umezaki; A. Kubo; M. Yanase; S. Sawada; Y.Sasaki; K. Akiyoshi
Biomaterials Science, 7, 1617 - 1622, 2019
DOI: 10.1039/c8bm01627e

[2] Intrinsically permeable polymer vesicles based on carbohydrate-conjugated poly(2-oxazoline)s synthesized using a carbohydrate-based initiator system
T. Nishimura; N. Sumi; Y. Koda; Y. Sasaki; K. Akiyoshi
Polymer Chemistry, 10, 691 - 697, 2019
DOI: 10.1039/c8py01502c

[1] Antigen Delivery Targeting Tumor-Associated Macrophages Overcomes Tumor Immune Resistance
D. Muraoka; N. Seo; T. Hayashi; Y. Tahara; K. Fujii; I. Tawara; Y. Miyahara; K. Okamori; H. Yagita; S. Imoto; R. Yamaguchi; M. Komura; S. Miyano; M. Goto; S. Sawada; A. Asai; H. Ikeda; K. Akiyoshi; N. Harada; H. Shiku
Journal of Clinical Investigation, 129, 3, 1278 - 1294, 2019
DOI: 10.1172/JCI97642

 

2018

[12] The improvement of calvarial bone healing by durable nanogel-crosslinked materials
P. Charoenlarp; A. K. Rajendran; R. Fujihara; T. Kojima; K. Nakahama; Y. Sasaki; K. Akiyoshi; M. Takechi; S. Iseki
J. of Biomaterials Science, Polymer Edition, 29, 15, 1876 - 1894, 2018
DOI: 10.1080/09205063.2018.1517403

 

[11] Nanogel tectonic porous 3D scaffold for direct reprogramming fibroblasts into osteoblasts and bone regeneration
Y. Sato; K. Yamamoto; S. Horiguchi; Y. Tahara; K. Nakai; S. Kotani; F. Oseko; G. Pezzotti; T. Yamamoto; T. Kishida; N. Kanamura; K. Akiyoshi; Osam Mazda
Scientific Reports, 8, 15284, 2018
DOI: 10.1038/s41598-018-33892-z

[10] Exosome‐mediated regulation of tumor immunology
N. Seo; K. Akiyoshi; H. Shiku
Cancer Science, 109, 10, 2998 - 3004, 2018
DOI: 10.1111/cas.13735

[9] Structural effects and lymphocyte activation properties of self-assembled polysaccharide nanogels for effective antigen delivery
R. Miura; Y. Tahara; S. Sawada; Y. Sasaki; K. Akiyoshi
Scientific Reports, 8, 16464, 2018
DOI: 10.1038/s41598-018-34885-8

 

[8] Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories
T. Nishimura; K. Akiyoshi
Advanced Science, 5, 11, 1800801, 2018
DOI: 10.1002/advs.201800801

 

[7] Nanogel Tectonics for Tissue Engineering: Protein Delivery Systems with Nanogel Chaperones
Y. Hashimoto; S. Mukai; Y. Sasaki; K. Akiyoshi
Advanced Healthcare Materials, 7, 23, 1800729, 2018
DOI: 10.1002/adhm.201800729

 

[6] Synthesis and Characterization of Shell-Crosslinked Glycopolymer Bilayer Vesicles
T. Nishimura; W. Toh; K. Akiyoshi
Macromolecular Rapid Communications, 39, 23, 1800384, 2018
DOI: 10.1002/marc.201800384

 

[5] Proteoliposome Engineering with Cell-Free Membrane Protein Synthesis: Control of Membrane Protein Sorting into Liposomes by Chaperoning Systems
M. Ando; S. Shikura; Y. Sasaki; K. Akiyoshi
Advanced Science, 5, 10, 1800524, 2018
DOI: 10.1002/advs.201800524

 

[4] Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents
T. Azegami; Y. Yuki; K, Hayashi; A. Hishikawa; S. Sawada; K. Ishige; K. Akiyoshi; H. Kiyono; H. Itoh
Journal of Hypertension, 36, 2, 387 - 394, 2018
DOI: 10.1097/HJH.0000000000001519

[3] Sequential Coating of Insulin Secreting Beta Cells within Multilayers of Polysaccharide Nanogels
T. Bal; D. C. Oran; Y. Sasaki; K. Akiyoshi
Macromolecular Bioscience, 18, 2018
DOI: 10.1002/mabi.201800001

[2] Design and Synthesis of PEGylated Amphiphilic Block Oligomers as Membrane Anchors for Stable Binding to Lipid Bilayer Membranes
D. Takahashi; Y. Koda; Y. Sasaki; K. Akiyoshi
Polymer J., 50, 787 - 797, 2018
DOI: 10.1038/s41428-018-0055-5

[1] Activated CD8+ T Cell Extracellular Vesicles Prevent Tumour Progression by Targeting of Lesional Mesenchymal Cell
N. Seo; Y. Shirakura; Y. Tahara; N. Harada; H. Ikeda; K. Akiyoshi; H. Shiku
Nature Communications, 9, 2018
DOI: 10.1038/s41467-018-02865-1

2017

[11] Nanogel-based nasal ghrelin vaccine prevents obesity
Tatsuhiko Azegami; Yoshikazu Yuki; Shin-ichi Sawada; Mio Mejima; Kazuya Ishige; Kazunari Akiyoshi; Hiroshi Itoh; Hiroshi Kiyono
Mucosal Immunology, 10, 1351 - 1360, 2017
DOI: 10.1038/mi.2016.137

[10] Nanogel-integrated pH Responsive Composite Hydrogels for Controlled Drug Delivery
Gunce. E. Cinay; Mohammad Alipour; Yoshihide Hashimoto; Yoshihiro Sasaki; Kazunari Akiyoshi; Seda Kizilel
ACS Biomater. Sci. Eng., 3, 370 - 380, 2017
DOI: 10.1021/acsbiomaterials.6b00670

[9] Self-assembled nanogels of carborane-bearing polysaccharides for boron neutron capture therapy
R. Kawasaki; Y. Sasaki; K. Akiyoshi
Chem. Lett., 46, 513 - 515, 2017
DOI: 10.1246/cl.161137

[8] Intracellular delivery and passive tumor targeting of a self-assembled nanogel containing carborane clusters for boron neutron capture therapy
R. Kawasaki; Y. Sasaki; K. Akiyoshi
Biochem. Biophys. Res. Commun., 483, 147 - 152, 2017
DOI: 10.1016/j.bbrc.2016.12.176

[7] Amylose engineering: phosphorylase-catalyzed polymerization of functional saccharide primers for glycobiomaterials
T. Nishimura; K. Akiyoshi
WIREs Nanomed Nanobiotechnol, 9, e1423, 2017
DOI: 10.1002/wnan.1423

[6] Effects of a polysaccharide nanogel-crosslinked membrane on wound healing
Hiroki Maeda; Hiroshi Kobayashi; Takayuki Miyahara; Yoshihide Hashimoto; Kazunari Akiyoshi
J. Biomed. Mater. Res. Part B, 105B, 544 - 550, 2017
DOI: 10.1002/jbm.b.33571

[5] Self-assembled nanogel of cholesterol-bearing xyloglucan as a drug delivery nanocarrier
S. Sawada; H. Yukawa; S. Takeda; Y. Sasaki; K. Akiyoshi
Journal of Biomaterials Science, Polymer Edition, 28, 1183 - 1198, 2017
DOI: 10.1080/09205063.2017.1320827

[4] Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells
A. Shimoda; Y. Tahara; S. Sawada; Y. Sasaki; K. Akiyoshi
Biochem. Biophys. Res. Commun., 491, 701 - 707, 2017
DOI: 10.1016/j.bbrc.2017.07.126

[3] Calcium-deficient Hydroxyapatite as a Potential Sorbent for Strontium
Y. Sekine; R. Motokawa; N. Kozai; T. Ohnuki; D. Matsumura; T. Tsuji; R. Kawasaki; K. Akiyoshi
Scientific Reports, 7, 2064, 2017
DOI: 10.1038/s41598-017-02269-z

[2] Bio-transporting Self-assembled Nanofactories using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy
T. Nishimura; Y. Sasaki; K. Akiyoshi
Adv. Mater., 29, 1702406, 2017
DOI: 10.1002/adma.201702406

[1] Self-assembled Polypeptide Nanogels with Enzymatically Transformable Surface as an siRNA Delivery Platform
T. Nishimura; A. Yamada; K. Umezaki; S. Sawada; S. Mukai; Y. Sasaki; K. Akiyoshi
Biomacromolecules, 18, 3913 - 3923, 2017
DOI: 10.1021/acs.biomac.7b00937

2016

[14] Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system
T. Niwa; Y. Sasaki; E. Uemura; S. Nakamura; M. Akiyama; M. Ando; S. Sawada; S. Mukai; T. Ueda; H. Taguchi; K. Akiyoshi
Scentific Reports, 5, 18025, 2016
DOI: 10.1038/srep18025

[13] A light sensitive self-assembled nanogel as a tecton for protein patterning materials
Tomoki Nishimura; Masahiro Takara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
Chem. Commun., 52, 1222 - 1225, 2016
DOI: 10.1039/C5CC08416D

[12] Self-assembled nanogels of cholesterol-bearing hydroxypropyl cellulose: A thermoresponsive building block for nanogel tectonic materials
Y. Tahara; M. Sakiyama; S. Takeda; T. Nishimura; S. Sawada; Y. Sasaki; K. Akiyoshi
Langmuir, 32, 47, 12283 - 12289, 2016
DOI: 10.1021/acs.langmuir.6b02406

[11] Nanoscopic Structural Investigation of Physically Cross-Linked Nanogels Formed from Self-Associating Polymers
Y. Sekine; H. Endo; H. Iwase; S. Takeda; S. Mukai; H. Fukazawa; K. C. Littrell; Y. Sasaki; K, Akiyoshi
J. Phys. Chem. B, 120, 46, 11996 - 12002, 2016
DOI: 10.1021/acs.jpcb.6b06795

[10] Saccharide Recognition Based on Self-assembly of Amphiphilic Phenylboronic Acid Azoprobes
Y. Tsuchido; R. Sato; N. Nodomi; T. Hashimoto; K. Akiyoshi; T. Hayashita
Langmuir, 32, 41, 10761 - 10766, 2016
DOI: 10.1021/acs.langmuir.6b02917

[9] Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor
T. Arakawa; Y. Kuroki; H. Nitta; P. Chouhan; K. Toma; S. Sawada; S. Takeuchi; T. Sekita; K. Akiyoshi; S. Minakuchi; K. Mitsubayashi
Biosensors and Bioelectronics, 84, 106 - 111, 2016
DOI: 10.1016/j.bios.2015.12.014

[8] Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes
K. Kamiya; R. Kawano; T. Osaki; K. Akiyoshi; S. Takeuchi
Nature Chemistry, 8, 881 - 889, 2016
DOI: 10.1038/nchem.2537

[7] Magnetically guided protein transduction by hybrid of nanogel chaperone with iron oxide nanoparticles
R. Kawasaki; Y. Sasaki; K. Katagiri; S. Mukai; S. Sawada; K. Akiyoshi
Angew. Chem. Int. Ed., 55, 11377 - 11381, 2016
DOI: 10.1002/anie.201602577

[6] Advanced Artificial Extracellular Matrices Using Amphiphilic Nanogel-Cross-Linked Thin Films To Anchor Adhesion Proteins and Cytokines
Y. Hashimoto; S. Mukai; S. Sawada; Y.Sasaki; K. Akiyoshi
ACS Biomater. Sci. Eng., 2, 3, 375 - 384, 2016
DOI: 10.1021/acsbiomaterials.5b00485

[5] Nanogel containing electrospun nanofibers as a platform for stable loading of proteins
A. Shimoda; Y. Chen; K. Akiyoshi
RSC Advances, 47, 40811 - 40817, 2016
DOI: 10.1039/C6RA05997J

[4] Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types
F. Momose; N. Seo; Y. Akahori; S. Sawada; T. Ogura; K. Akiyoshi; H. Shiku
PLOS ONE, 11, 4, e0154134, 2016
DOI: 10.1371/journal.pone.0154134

[3] Engineering hybrid exosomes by membrane fusion with liposomes
Y. Sato; K. Umezaki; S.Sawada; S. Mukai; N. Harada; H. Shiku; K. Akiyoshi
Scentific Reports, 6, 21933, 2016
DOI: 10.1038/srep21933

[2] Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA
A. Shimoda; K. Ueda; S. Nishiumi; N. Murata-Kamiya; S. Mukai; S. Sawada; T. Azuma; M. Hatakeyama; K. Akiyoshi
Scientific Report, 6, 18346, 2016
DOI: 10.1038/srep18346

[1] Liposome chaperon in cell-free membrane protein synthesis: One-step preparation of KcsA-integrated liposomes and electrophysiological analysis by the planar bilayer method
M. Ando; M. Akiyama; D. Okuno; M. Hirano; T. Ide; S. Sawada; Y. Sasaki; K. Akiyoshi
Biomaterials Science , 4, 258 - 264, 2016
DOI: 10.1039/c5bm00285k

2015

[14] Simple Preparation and Characterization of Viscoelastic Gels Inducedby Multiple Intermolecular Interactions Using Low-Molecular-Weight Species
T. Kubo; K. Kuroda; T. Naito; S. Mukai; T. Sano; K. Akiyoshi; K. Otsuka
Bull. Chem. Soc. Jpn., 88, 11, 1575 - 1580, 2015
DOI: 10.1246/bcsj.20150209

[13] Current advances in self-assembled nanogel delivery systems for immunotherapy
Y. Tahara; K. Akiyoshi
Adv. Drug Deliv. Rev., 95, 65 - 76, 2015
DOI: 10.1016/j.addr.2015.10.004

[12] Amylose-Based Cationic Star Polymers for siRNA Delivery
T. Nishimura; K. Umezaki; S. Mukai; S. Sawada; K. Akiyoshi
BioMed Research International, 6, 962941, 2015
DOI: 10.1155/2015/962941

[11] Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent
M. Chan; J. Lux; T. Nishimura; K Akiyoshi; A. Almutairi
Biomacromolecules, 16, 9, 2964 - 2971, 2015
DOI: 10.1021/acs.biomac.5b00867

[10] Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques
Y. Fukuyama; Y. Yuki; Y. Katakai; N. Harada; S. Takeda; M. Mejima; S. Joo; S. Kurokawa; S. Sawada; H. Shibata; E. J. Park; K. Fujihashi; D. E. Briles; Y. Yasutomi; H. Tsukada K. Akiyoshi H. Kiyono
Mucosal Immunology, 8, 1144 - 1153, 2015
DOI: 10.1038/mi.2015.5

[9] Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity
H. Takahashi; K. Akiyoshi; K. Kuroda
Chem. Commun., 51, 12597 - 12600, 2015
DOI: 10.1039/C5CC02012C

[8] Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid
R. Ogawa; K. Nagao; K. Taniuchi; M. Tsuchiya; U. Kato; Y. Hara; T. Inaba; T. Kobayashi; Y. Sasaki; K. Akiyoshi; M. Watanabe-Takahashi; K. Nishikawa; M. Umeda
PLOS ONE, 10, e0131668, 2015
DOI: 10.1371/journal.pone.0131668

[7] Nanocarrier-integrated microspheres: Nanogel tectonic engineering for advanced drug delivery systems
Y. Tahara; S. Mukai; S. Sawada; Y. Sasaki; K. Akiyoshi
Advanced Materials, 27, 34, 5080 - 5088, 2015
DOI: 10.1002/adma.201501557

[6] The design of phenylboronic acid azoprobe–polyamidoamine dendrimer complexes as supramolecular sensors for saccharide recognition in water
Y. Tsuchido; Y. Sasaki; K. Aimu; T. Hashimoto ; K. Akiyoshi; T. Hayashita
New J. Chem, 39, 2620 - 2626 , 2015
DOI: 10.1039/C4NJ01309C

[5] Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model
T. Sato; N.Alles; M. Khan; K. Nagano; M. Takahashi; Y. Tamura; A. Shimoda; K. Akiyoshi; K. Ohya; K. Aoki
Int. J. Nanomedicine, 10, 1 - 15, 2015
DOI: 10.2147/IJN.S61566

[4] Glyco Star Polymers as Helical Multivalent Host and Biofunctional Nano-Platform
T. Nishimura; S. Mukai; S. Sawada; K. Akiyoshi
ACS Macro Lett., 4, 4, 367 - 371, 2015
DOI: 10.1021/acsmacrolett.5b00049

[3] Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold
Y. Hashimoto; S. Mukai; S. Sawada; K. Akiyoshi
Biomaterials, 37, 107 - 115, 2015
DOI: 10.1016/j.biomaterials.2014.10.045

[2] Effective CpG DNA delivery using amphiphilic cycloamylose nanogels
Y. Tahara; J. Yasuoka; Y. Sasaki; K. Akiyoshi
Biomaterials Science, 3, 256 - 264, 2015
DOI: 10.1039/C4BM00293H

[1] Protein nanogelation using vitamin B6-bearing pullulan: effect of zinc ions
Y. Tsuchido; Y. Sasaki; S. Sawada; K. Akiyoshi
Polymer Journal, 47, 201 - 205, 2015
DOI: 10.1038/pj.2014.120

2014

[6] Dual-sugar Nanogel Comprising beta-1,3-Glucan and Cholesterol-bearing Dextran for Protein Delivery Targeting Antigen Presenting Cells
Y. Maegawa; S. Mochizuki; Y. Sanada; K. Akiyoshi; K. Sakurai
Chem. Lett., 43, 5, 652 - 654, 2014
DOI: 10.1246/cl.131201

[5] Therapeutic Effect of Nanogel-Based Delivery of Soluble FGFR2 with S252W Mutation on Craniosynostosis
M. Yokota; Y. Kobayashi; J. Morita; H. Suzuki; Y. Hashimoto; Y. Sasaki; K. Akiyoshi; K. Moriyama
PLOS ONE, 9, 7, 2014
DOI: 10.1371/journal.pone.0101693
[e101693]:Number of citation

[4] Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Antitumor Immunity
D. Muraoka; N. Harada; T. Hayashi; Y. Tahara; F. Momose; S. Sawada; S. Mukai; K. Akiyoshi; H. Shiku
ACS Nano, 8, 9, 9209 - 9218, 2014
DOI: 10.1021/nn502975r

[3] Development and Potential Theranostic Applications of a Self-Assembled Hybrid of Magnetic Nanoparticle Clusters with Polysaccharide Nanogels
K. Katagiri; K. Ohta; K. Inumaru; K. Hayashi; Y. Sasaki; K. Akiyoshi
ChemPlusChem, 79, 11, 1631 - 1637, 2014
DOI: 10.1002/cplu.201402159

[2] Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
H. Fujii; M. Shin-Ya; S. Takeda; Y. Hashimoto; S. Mukai; S. Sawada; T. Adachi; K. Akiyoshi; T. Miki; O. Mazda
Cancer Sci., 105, 12, 1616 - 1625, 2014
DOI: 10.1111/cas.12547

[1] Microrheology of polysaccharide nanogel-integrated system
Y. Sekine; K. Okazaki; T. Ikeda-Fukazawa; M. Ichikawa; K. Yoshikawa; S. Mukai; K. Akiyoshi
Colloid Polym. Sci., 292, 2, 325 - 331, 2014
DOI: 10.1007/s00396-013-3069-8

2013

[14] A polyion complex nanogel
M. Takeo; T. Mori; T. Niidome; S. Sawada; K. Akiyoshi; Y. Katayama
J. Collod. Interf. Sci., 390, 1, 78 - 84, 2013
DOI: 10.1016/j.jcis.2012.09.015

[13] Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae
I. Kong; A. Sato; Y. Yuki; T. Nochi; H. Takahashi; S. Sawada; M. Mejima; S. Kurokawa; K. Okada; S. Sato; D. E. Briles; J. Kunisawa; Y. Inoue; K. Akiyoshi; H. Kiyono
Infect. Immun., 81, 5, 1625 - 1634, 2013
DOI: 10.1128/iai.00240-13

[12] Self-assembled pH sensitive cholesteryl pullulan nanogel as a protein delivery vehicle
N. Morimoto; S.Hirano; H. Takahashi; S. Loethen; D. H. Thompson; K. Akiyosh
Biomacromolecules, 14, 1, 56 - 63, 2013
DOI: 10.1021/bm301286h

[11] Templated nucleation of hybrid iron oxide nanoparticles on polysaccharide nanogels
K. Katagiri; K. Ohta; K. Koumoto; K. Kurosu; Y. Sasaki; K. Akiyoshi
Colloid Polym. Sci., 291, 1375 - 1380, 2013
DOI: 10.1007/s00396-012-2868-7

[10] Nanogel bottom-up gel biomaterials for protein delivery: photopolymerization of an acryloyl-modified polysaccharide nanogel macromonomer
Y. Tahara; S. Kosuge; S. Sawada; K. Akiyoshi
Reactive and Functional Polymers, 73, 7, 958 - 964, 2013
DOI: 10.1016/j.reactfunctpolym.2013.02.002

[9] Cyclodextrin triggered dimensional changes of polysaccharide nanogel integrated hydrogels at nanometer resolution
M. Gao; S. Toita; S. Sawada; K. Akiyoshi; B. T. Stokke
Soft Matter, 9, 5178 - 5185, 2013
DOI: 10.1039/C3SM27662G

[8] Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2
M. Hara-Yokoyama; K. Terasawa; S. Ichinose; A. Watanabe; K. A. Podyma-Inoue; K. Akiyoshi; Y. Igarashi; M. Yanagishita
Bioorganic & Medicinal Chemistry Letters, 23, 2220 - 2224, 2013
DOI: 10.1016/j.bmcl.2013.01.083

[7] Polysaccharide-hair cationic polypeptide nanogels: Self-assembly and enzymatic polymerization of amylose primer modified cholesteryl poly(L-lysine)
N. Morimoto; M. Yamazaki; J. Tamada; K. Akiyoshi
Langmuir, 29, 24, 7509 - 7514, 2013
DOI: 10.1021/la3047774

[6] Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells
A. Tamura; G. Ikeda; J-H. Seo; K. Tsuchiya; H. Yajima; Y. Sasaki; K. Akiyoshi; N. Yui
Scientific Report, 3, 2252, 2013
DOI: 10.1038/srep02252

[5] Nanogel-based antigen-delivery system for nasal vaccines
Y. Yuki; T. Nochi; G. Kong; H.Takahashi; S. Sawada; K. Akiyoshi; H. Kiyono
Biotechnol. Genet. Eng. Rev., 29, 61 - 72, 2013
DOI: 10.1080/02648725.2013.801226

[4] Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nanoencapsulation
H. Takahashi; S. Sawada; K.Akiyoshi
Biomaterials Science, 1, 842 - 849, 2013
DOI: 10.1039/C3BM00178D

[3] Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effective protein refolding
S. Takeda; H. Takahashi; S. Sawada; Y. Sasaki; K. Akiyoshi
RSC Advances, 3, 48, 25716 - 25718, 2013
DOI: 10.1039/C3RA44572K

[2] The Effect of Hydrophilic Ionic Liquids 1-Ethyl-3-Methylimidazolium Lactate and Choline Lactate on Lipid Vesicle Fusion
E. H. Hayakawa; E. Mochizuki; T. Tsuda; K. Akiyoshi; H. Matsuoka; S. Kuwabata
PLOS ONE, 8, 12, e85467, 2013
DOI: 10.1371/journal.pone.0085467

[1] Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans
M. Itoh; H. Kato; T. Suganami; K. Konuma; Y. Marumoto; S. Terai; H. Sakugawa; S. Kanai; M. Hamaguchi; T. Fukaishi; S. Aoe; K. Akiyoshi; Y. Komohara; M. Takeya; I. Sakaida; Y. Ogawa
PLOS ONE, 8, 12, e82163, 2013
DOI: 10.1371/journal.pone.0082163

2012

[10] Biodegradable Nanogel-integrated Hydrogels for Sustained Protein Delivery
A. Shimoda; Y. Yamamoto; S. Sawada; K. Akiyoshi
Macromol. Res., 20, 266 - 270, 2012
DOI: 10.1007/s13233-012-0054-x

[9] Self-assembled Nanogel Engineering for Advanced Biomedical Technology
Y.Sasaki; K. Akiyoshi
Chem. Lett., 41, 202 - 208, 2012
DOI: 10.1246/cl.2012.202

[8] Shear flow-induced nanotubulation of surface-immobilized liposomes
Y. Sekine; K. Abe; A. Shimizu; Y. Sasaki; S. Sawada; K. Akiyoshi
RSC Advances, 2, 2682 - 2684, 2012
DOI: 10.1039/C2RA00629D

[7] Synthesis and Biological Properties of Highly Sequence-Specific Alkylating N-Methylpyrrole-N-Methylimidazole (PI) Polyamide Conjugates
G. Kashiwazaki; T. Bando; T. Yoshidome; S. Masui; T. Takagaki; K. Hashiya; G. Pandian; J. Yasuoka; K. Akiyoshi; H. Sugiyama
J. Med. Chem., 55, 5, 2057 - 2066, 2012
DOI: 10.1021/jm201225z

[6] Injectable Hydrogel for Sustained Protein Release by Salt-Induced Association of Hyaluronic Acid Nanogel
T. Nakai; T. Hirakura; Y. Sakurai; T. Shimoboji; M. Ishigai; K. Akiyoshi
Macromol. Biosci., 12, 475 - 483, 2012
DOI: 10.1002/mabi.201100352

[5] Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells
Y. Kishia; T. Higuchia; S. Phoon; Y. Sakamakia; K. Kamiya; G. Riemekasten; K. Akiyoshi; M. Weigert; T. Tsubata
Proc. Natl. Acad. Sci. USA, 109, 7811 - 7816, 2012
DOI: 10.1073/pnas.1204509109

[4] Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery
A. Shimoda; S. Sawadad; A. Kano; A. Maruyama; A. Moquin; F. M. Winnik; K. Akiyoshi
Colloids and Surfaces B: Biointerfaces, 99, 38 - 44, 2012
DOI: 10.1016/j.colsurfb.2011.09.025

[3] Exploitation of a novel polysaccharide nanogel cross-linking membrane for guided bone regeneration (GBR)
T. Miyahara; M. Nyan; A. Shimoda; Y. Yamamoto; S. Kuroda; M. Shiota; K. Akiyoshi; S. Kasugai
J. Tissue Engineering and Regererative Medicine, 6, 666 - 672, 2012
DOI: 10.1002/term.475

[2] Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering
M. Fujioka-Kobayashi; M. S. Ota; A. Shimoda; K. Nakahama; K. Akiyoshi; Y. Miyamoto; S. Iseki
Biomaterials, 33, 7613 - 7620, 2012
DOI: 10.1016/j.biomaterials.2012.06.075

[1] A hybrid hydrogel biomaterial by nanogel engineering: bottom-up design with nanogel and liposome building blocks to develop a multi-drug delivery system
Y. Sekine; Y. Moritani; T. Ikeda-Fukazawa; Y. Sasaki; K. Akiyoshi
Advance Healthcare Materials, 1, 6, 722 - 728, 2012
DOI: 10.1002/adhm.201200175

2011

[14] Amphiphilic polysaccharide nanoballs: a new building block for nanogel biomedical engineering and artificial chaperone
H. Takahashi; S. Sawada; K. Akiyoshi
ACS Nano, 5, 1, 337 - 345, 2011
DOI: 10.1021/nn101447m

[13] Metal coordinative-crosslinked polysaccharide nanogels with redox sensitivity
Y. Sasaki; T. Hirakura; S. Sawada; K Akiyoshi
Chem. Lett., 40, 182 - 183, 2011
DOI: 10.1246/cl.2011.182

[12] Cyclodextrin-responsive nanogel as an artificial chaperone for horseradish peroxidase
S. Sawada; Y. Sasaki; Y. Nomura; K. Akiyoshi
Colloid Polym. Sci., 289, 685 - 691, 2011
DOI: 10.1007/s00396-010-2361-0

[11] Amphiphilic Polysaccharide Nanogels as an Artificial Chaperone in Cell-Free Protein Synthesis
Y. Sasaki; W. Asayama; T. Niwa; S. Sawada; T. Ueda; H. Taguchi; K. Akiyoshi
Macromol. Bioscience, 11, 814 - 820, 2011
DOI: 10.1002/mabi.201000457

[10] Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide
Y. Sasaki; Y. Tsuchido; S. Sawada; K. Akiyoshi
Polym. Chem., 2, 1267 - 1270, 2011
DOI: 10.1039/C1PY00100K

[9] Cell specific peptide-conjugated polysaccharide nanogels for protein delivery
A. Shimoda; S. Sawada; K. Akiyoshi
Macromol. Bioscience, 11, 882 - 888, 2011
DOI: 10.1002/mabi.201000491

[8] The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate
K. Watanabe; Y. Tsuchiya; Y. Kawaguchi; S. Sawada; H. Ayame; K. Akiyoshi; T. Tsubata
Biomaterials, 32, 5900 - 5905, 2011
DOI: 10.1016/j.biomaterials.2011.04.058

[7] Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents
MingXing Chu; T. Shirai; D. Takahashi; T. Arakawa; H. Kudo; K. Sano; S. Sawada; K. Yano; Y. Iwasaki; K. Akiyoshi; M. Mochizuki; K. Mitsubayashi
Biomedical Microdevices, 13, 603 - 611, 2011
DOI: 10.1007/s10544-011-9530-x

[6] Nanogel-based scaffold delivery of prostaglandin E2 receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice
P. Kamolratanakul; T. Hayata; Y. Ezura; A. Kawamata; C. Hayashi; Y. Yamamoto; H. Hemmi; M. Nagao; R. Hanyu; T. Notomi; T. Nakamoto; T. Amagasa; K. Akiyoshi; M. Noda
Arthritis and Rheumatism, 63, 4, 1021 - 1033, 2011
DOI: 10.1002/art.30151

[5] Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2
S. Toita; S. Sawada; K. Akiyoshi
J. Controlled Release, 155, 1, 54 - 59, 2011
DOI: 10.1016/j.jconrel.2010.12.008

[4] Synthesis and in situ insertion of a site-specific fluorescently labeled membrane protein into cell-sized liposomes
T. Ohtsuka; S. Neki; T. Kanai; K. Akiyoshi; S. M. Nomura; T. Ohtsuki
Analytical Biochemistry, 418, 97 - 101, 2011
DOI: 10.1016/j.ab.2011.06.026

[3] Cadherin-integrated liposomes with potential application in a drug delivery system
K. Kamiya; K. Tsumoto; T. Yoshimura; K. Akiyoshi
Biomaterials, 32, 9899 - 9907, 2011
DOI: 10.1016/j.biomaterials.2011.09.008

[2] Artificial chaperone polysaccharide nanogels for protein delivery: A thermodynamic study of protein-nanogel interactions using fluorescence correlation spectroscopy
Y. Sasaki; D. Iida; H. Takahashi; S. Sawada; K. Akiyoshi
Current Drug Discovery Technologies, 8, 4, 308 - 313, 2011
DOI: 10.2174/157016311798109371

[1] The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvatiae
K. Nagano; N. Alles; A. H. Mian; A. Shimoda; N. Morimoto; Y. Tamura; H. Shimokawa; K. Akiyoshi; K. Ohya; K. Aoki
J. Bone Miner. Metab., 29, 671 - 681, 2011
DOI: 10.1007/s00774-011-0270-z

2010

[11] Functional cycloamylose-based　biomaterial: application in a gene delivery system
S. Toita; N. Morimoto; K. Akiyoshi
Biomacromolecules, 11, 2, 397 - 401, 2010
DOI: 10.1021/bm901109z

[10] Nano-encapsulation of lipase by self-assembled nanogels: induction of high enzyme activity and thermal　stabilization
S. Sawada; K. Akiyoshi
Macromol. Biosci., 10, 353 - 358, 2010
DOI: 10.1002/mabi.200900304

[9] Hybrid hyaluronan hydrogel encapsulated nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function
T. Hirakura; K. Yasugi; T. Nemoto; M. Sato; T. Shimoboji; Y. Aso; N. Morimoto; K. Akiyoshi
J. Controlled Release, 142, 3, 483 - 489, 2010
DOI: 10.1016/j.jconrel.2009.11.023

[8] Development of an Artificial Chaperone System Based on Cyclodextrin
Y. Sasaki; K. Akiyoshi
Current Pharmaceutical Biotechnology, 11, 300 - 305, 2010
DOI: 10.2174/138920110791111951

[7] Nanogel antigenic protein delivery system for adjuvant-free intranasal vaccines
T. Nochi; Y. Yuki; H. Takahashi; S. Sawada; M. Mejima; T. Kohda; N. Harada; G. Kong; A. Sato; N. Kataoka; D. Tokuhara; S. Kurokawa; Y. Takahashi; H. Tsukada; S. Kozaki; K. Akiyoshi; H. Kiyono
Nature Materials, 9, 572 - 578, 2010
DOI: 10.1038/nmat2784

[6] Direct integration of cell-free synthesized connexin-43 into liposomes utilizing chaperone-like function of liposomes
Y. Moritani; S. Nomura; I. Morita; K. Akiyoshi
The FEBS Journal, 277, 16, 3343 - 3352, 2010
DOI: 10.1111/j.1742-4658.2010.07736.x

[5] Polysaccharide nanogel-cyclodextrin system as artificial chaperone for in vitro protein synthesis of green fluorescent protein
Y. Sasaki; Y. Nomura; S. Sawada; K. Akiyoshi
Polymer Journal, 42, 823, 2010
DOI: 10.1038/pj.2010.73

[4] Preparation of connexin43-integrated giant liposomes by a baculovirus expression-liposome fusion method
K. Kamiya; K. Tsumoto; S. Arakawa; S. Shimizu; I. Morita; T. Yoshimura; K. Akiyoshi
Biotechnology and Bioengineering, 107, 5, 836 - 843, 2010
DOI: 10.1002/bit.22845

[3] Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice
N. Alles; N. S. Soysa; J. Hayashi; M. Khan; A. Shimoda; H. Shimokawa; O. Ritzeler; K. Akiyoshi; K. Aoki; K. Ohya
Endocrinology, 151, 10, 4626 - 4634, 2010
DOI: 10.1210/en.2010-0399

[2] DNA separation by cholesterol-bearing pullulan nanogels
K. Kondo; N. Kaji; S. Toita; Y. Okamoto; M. Tokeshi; K. Akiyoshi; Y. Baba
Biomicrofluidics, 4, 32210 - 33218, 2010
DOI: 10.1063/1.3479997

[1] Nanogel engineering for new nanobiomaterials: From chaperoning engineering to biomedical applications
Y. Sasaki; K. Akiyoshi
The Chemical Record, 10, 366 - 376, 2010
DOI: 10.1002/tcr.201000008

2009

[20] Interaction of Nanogel with Cyclodextrin or Protein: Study by Dynamic Light Scattering and Small-angle Neutron Scattering
Inomoto N; Osaka N; Suzuki T; Hasegawa U; Ozawa Y; Endo H; Akiyoshi K; Shibayama M
Polymer, 50, 541 - 546, 2009

[19] Cycloamylose-based Biomaterial: Nanogels of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery
Toita S; Soma Y; Morimoto N; Akiyoshi K
Chem. Lett., 38, 1114 - 1115, 2009

[18] Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells
Tsutsumi H; Nomura W; Abe S; Mino T; Masuda A; Ohashi N; Tanaka T; Ohba K; Yamamoto N; Akiyoshi K; Tamamura H
Angew. Chem.-Int. Edit. , 48, 9164 - 9166, 2009

[17] Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin E1 on wound healing
H. Kobayashi; O. Katakura; N. Morimoto; K. Akiyoshi; S. Kasugai
J. Biomed. Mater. Res. B., 91, 55 - 60, 2009

[16] Raspberry-Like Assembly of Cross-Linked Nanogels for Protein Delivery
U. Hasegawa; S. Sawada; T. Shimizu; T. Kishida; E. Otsuji; O. Mazda; K. Akiyoshi
J. Controlled Release, J. Control. Release., 140, 312 - 317, 2009

[15] A Nano Sensory Device Fabricated on a Liposome for Detection of Chemical Signals
Y. Sasaki; Y. Shioyama; W.-J. Tian; J. Kikuchi; S. Hiyama; Y. Moritani; T. Suda
Biotechnology and Bioengineering, 2009

[14] The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity
S. Boridy; H. Takahashi; K. Akiyoshi; D. Maysinger
Biomaterials, 30, 29, 5583 - 5591, 2009

[13] A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring
M. X. Chu; H. Kudo; T. Shirai; K. Miyajima; H. Saito; N. Morimoto; K. Yano; Y. Iwasaki; K. Akiyoshi; K. Mitsubayashi
Biomedical Microdevices, 11, 4, 837 - 842, 2009

[12] Self-assembeld nanogel of hydrophobized dendritic dextrin for protein delivery
Y. Ozawa; S. Sawada; N. Morimoto; K. Akiyoshi
Macromol. Biosci., 9, 694 - 701, 2009

[11] Interaction of Nanogel with Cyclodextrin or Protein: Study by Dynamic Light Scattering and Small-angle Neutron Scattering
N. Inomoto; N. Osaka; T. Suzuki; U. Hasegawa; Y. Ozawa; H. Endo; K. Akiyoshi; M. Shibayama
Polymer, 50, 541 - 546, 2009

[10] Polysaccharide nanogel delivery of a TNF-? and RANKL antagonist peptide allows systemic prevention of bone loss
Alles, Neil; Soysa, Niroshani S.; Hussain, M. D. Anower; Tomomatsu, Nobuyoshi; Saito, Hiroaki; Baron, Roland; Morimoto, Nobuyuki; Aoki, Kazuhiro; Akiyoshi, Kazunari; Ohya, Keiichi
European Journal of Pharmaceutical Sciences, 37, 2, 83 - 88, 2009
<5月12日>

[9] Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes
Kaneda, Makoto; Nomura, Shin-ichiro M; Ichinose, Shizuko; Kondo, Satoshi; Nakahama, Ken-ichi; Akiyoshi, Kazunari; Morita, Ikuo
Biomaterials, 30, 23-24, 3971 - 3977, 2009
<5月6日>

[8] Interaction of self-assembled cationic nanogels with oligo-DNA and function as artificial nucleic acid chaperone
Morimoto, Nobuyuki; Tamada, Junko; Sawada, Shin-ichi; Shimada, Naohiko; Kano, Arihiro; Maruyama, Atsushi; Akiyoshi, Kazunari
Chemistry Letters, 38, 5, 496 - 497, 2009
<4月18日>

[7] Propagation and amplification of molecular information using a photo-responsive molecular switch
Mukai M; Maruo K; Kikuchi J; Sasaki Y; Hiyama S; Moritani Y; Suda T
Supramolecular Chem., 50, 2, 541, 2009
<4月>

[6] Enzyme-responsive artificial chaperone system with amphiphilic amylose primer
Morimoto, Nobuyuki; Ogino, Naruhito; Narita, Tadashi; Akiyoshi, Kazunari
Journal of Biotechnology, 140, 3-4, 246 - 249, 2009
<3月25日>

[5] Composite nanomaterials by self-assembly and controlled crystallization of poly(2-isopropyl-2-oxazoline)-grafted polysaccharides
Morimoto, Nobuyuki; Obeid, Rodolphe; Yamane, Setsuko; Winnik, Francoise M; Akiyoshi, Kazunari
Soft Matter, 5, 8, 1597 - 1600, 2009
<3月23日>

[4] Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor
Hayashi, Chikako; Hasegawa, Urara; Saita, Yoshitomo; Hemmi, Hiroaki; Hayata, Tadayoshi; Nakashima, Kazuhisa; Ezura, Yoichi; Amagasa, Teruo; Akiyoshi, Kazunari; Noda, Masaki
Journal of Cellular Physiology, 220, 1, 1 - 7, 2009
<3月19日>

[3] Nanogel-calcium phosphate hybrid nanoparticles with negative or positive charges for potential biomedical applications
Yamane, Setsuko; Sugawara, Ayae; Sasaki, Yoshihiro; Akiyoshi, Kazunari
Bulletin of the Chemical Society of Japan, 82, 3, 416 - 418, 2009
<3月12日>

[2] Hybrid nanoapatite by polysaccharide nanogel-templated mineralization
Yamane, Setsuko; Sugawara, Ayae; Watanabe, Akihiko; Akiyoshi, Kazunari
Journal of Bioactive and Compatible Polymers, 24, 2, 151 - 168, 2009
<3月>

[1] ANA Deficiency Enhances Bone Morphogenetic Protein-induced Ectopic Bone Formation via Transcriptional Events
Miyai, Kentaro; Yoneda, Mitsuhiro; Hasegawa, Urara; Toita, Sayaka; Izu, Yayoi; Hemmi, Hiroaki; Hayata, Tadayoshi; Ezura, Yoichi; Mizutani, Shuki; Miyazono, Kohei; Akiyoshi, Kazunari;; Yamamoto, Tadashi; Noda, Masaki
Journal of Biological Chemistry, 284, 16, 10593 - 10600, 2009
<2月20日>

2008

[14] Direct preparation of giant proteo-liposomes by in vitro membrane protein synthesis
Nomura SM; Kondoh S; Asayama W; Asada A; Nishikawa S; Akiyoshi K
J. Biotechnol., 133, 190 - 195, 2008

[13] Nanogel DDS enables sustained release of a cytokine for tumor immunotherapy
Shimizu T; Kishida T; Hasegawa U; Ueda Y; Imanishi J; Yamagishi H; Akiyoshi K; Otsuji E; Mazda O
Biochem. Biophys. Res. Commun., 367, 330 - 335, 2008

[12] Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel (CHP-HER2)
Kageyama S; Kitano S; Hirayama M; Nagata Y; Imai H; Shiraishi T; Akiyoshi K; Scott A; Murphy R; Hoffman E; Old L; Katayama N; Shiku H
Cancer Sci., 99, 601 - 607, 2008

[11] Covalent immobilization of antibody fragments on well-defined polymer brushes via site-directed method
Iwata R; Iwasaki Y; Akiyoshi K
Colloids Surf., B: Biointerfaces, 62, 288 - 298, 2008

[10] Comparison of Refolding Activities between Nanogel Artificial Chaperone and GroEL Systems
Asayama W; Sawada S; Taguchi H; Akiyoshi K
Int. J. Biol. Macromol., 42, 241 - 246, 2008

[9] Protein-conjugated QD effectively delivered into living cells by a cationic nanogel
Toita S; Hasegawa U; Koga H; Sekiya I; Muneta T; Akiyoshi K
J. Nanosci. Nanotechnol., 8, 1 - 7, 2008

[8] Self-assembled cationic nanogels for intracellular protein delivery system
Ayame H; Morimoto N; Akiyoshi K
Bioconjugate Chem., 19, 882 - 890, 2008

[7] Thermo-responsive hydrogels with nanodomains: rapid shrinking of nanogel-crosslinking hydrogel of poly (N-isopropyl acrylamide)
Morimoto N; Ohki T; Kurita K; Akiyoshi K
Macromol. Rapid Commun., 29, 672 - 676, 2008

[6] Glucose sensor using phospholipid polymer-based enzyme immobilization method
Kudo H; Yagi T; Chu MX; Saito H; Morimoto M; Iwasaki Y; Akiyoshi K; Mitsubayashi K
Anal. Bioanal. Chem., 391, 4, 1269 - 1274, 2008

[5] Dual Stimuli-Responsive Nanogels by Self-Assembly of Polysaccharides Lightly Grafted with Thiol-Terminated Poly(N-isopropylacrylamide) Chains
Morimoto N; Qiu XP; Winnik FM; Akiyoshi K
Macromolecules, 41, 16, 5985 - 5987, 2008

[4] Fluorescent sensor responsive to local viscosity and its application to the imaging of liquid-ordered domain in lipid membranes
Yasuhara K; Sasaki Y; Kikuchi J
Colloids Surf., B: Biointerfaces, 57, 1, 145 - 149, 2008

[3] A photo-responsive cholesterol capable of inducing a morphological transformation of the liquid-ordered microdomain in lipid bilayers
Yasuhara K; Sasaki Y; Kikuchi J
Colloid Polym. Sci., 286, 14-15, 1675 - 1680, 2008

[2] Siloxane-crosslinked Polysaccharide Nanogels for Potential Biomedical Applications
Yamane S; Sasaki Y; Akiyoshi K
Chem. Lett., 37, 12, 1282, 2008

[1] Interaction of Nanogel with Cyclodextrin or Protein: Study by Dynamic Light Scattering and Small-angle Neutron Scattering
Inomoto N; Osaka N; Suzuki T; Hasegawa U; Ozawa Y; Endo H; Akiyoshi K; Shibayama M
Polymer, 50, 2, 541, 2008

2007

[12] Botryoidal assembly of cholesteryl-pullulan/ poly(N-isopropylacrylamide) nanogels
Morimoto N; Winnik FM; Akiyoshi K
Langmuir, 23, 217 - 223, 2007

[11] Enzyme-Responsive Molecular Assembly System with Amylose-Primer Surfactants
Morimoto N; Ogino N; Narita T; Kitamura S; Akiyoshi K
J. Am. Chem. Soc., 129, 458, 2007

[10] Enzyme-degradable phosphorylcholine porous hydrogels cross-linked with polyphosphoesters for biocompatible cell matrices
Wachiralarpphaithoon C; Iwasaki Y; Akiyoshi K
Biomaterials, 28, 984, 2007

[9] Intracellular Delivery of Nanogel-Quantum Dot Hybrid Nanoparticles into Human Periodontal Ligament Cells
Fukui T; Kobayashi H; Hasegawa U; Nagasawa T; Akiyoshi K; Ishikawa I
Drug Metabolism Lett., 1, 131 - 135, 2007

[8] Possible molecular evolution of biomembranes: from single-chain to double-chain lipids
Gotoh M; Sugawara A; Akiyoshi K; Matsumoto I; Ourisson G; Nakatani Y
Chem. Biodiversity, 4, 837 - 848, 2007

[7] Self-assembled Nanogels of Cholesteryl-modified Polysaccharides: Effect of the Polysaccharide Structure on Their Association Characteristics in the Dilute and Semi-dilute Regimes
Akiyama E; Morimoto N; Kujawa P; Winnik FM; Akiyoshi K
Biomacromolecules, 8, 2366 - 2373, 2007

[6] Nanogel-based Delivery System Enhances PGE₂Effects on Bone Formation
Kato N; Hasegawa U; Morimoto N; Saita Y; Nakashima K; Ezura Y; Kurosawa H; Akiyoshi K; Noda M
J. Cell. Biochem., 101, 1063 - 1070, 2007

[5] Selective biorecognition and preserving cell function on carbohydrates-immobilized phosphorylcholine polymers
Iwasaki Y; Takamiya U; Shinohara Y; Kurita K; Akiyoshi K
Biomacromolecules, 8, 2788 - 2794, 2007

[4] Cell-specific delivery of polymeric nanoparticles to carbohydrate tagging cells
Iwasaki Y; Maie H; Akiyoshi K
Biomacromolecule, 8, 3162 - 3168, 2007

[3] Surface modification with well-defined biocompatible triblock copolymers ? Improvement of biointerfacial phenomena on a poly(dimethylsiloxane) surface
Iwasaki Y; Takamiya M; Iwata R; Yusa S; Akiyoshi K
Colloids Surf., B: Biointerfaces, 57, 226 - 236, 2007

[2] Novel thermoresponsive polymers having biodegradable phosphoester backbones
Iwasaki Y; Wachiralarpphaithoon C; Akiyoshi K
Macromolecules, 40, 8136 - 8138, 2007

[1] Salt Effect on the Heat-Induced Association Behavior of Gold Nanoparticles Coated with Poly(N-isopropylacrylamide) Prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization
Yusa S; Fukuda K; Yamamoto T; Iwasaki Y; Watanabe A; Akiyoshi K; Morishima Y
Langmuir., 23, 12842 - 12848, 2007

2006

[12] High functional hollow fiber membrane modified with phospholipid polymers for a liver assist bioreactor
Ho Ye S; Watanabe J; Takai M; Iwasaki Y; Ishihara K
Biomaterials, 27, 1955 - 1962, 2006

[11] Poly(MPC-co-BMA) coating reduces the adhesion of Candida albicans to poly(methyl methacrylate) surfaces
Hatsuno K; Mukohyama H; Horiuchi S; Iwasaki Y; Yamamoto N; Akiyoshi K; Taniguchi H
Prosthodont Res. Pract., 5, 21 - 25, 2006

[10] Nanogel-template mineralization: Polymer-calcium phosphate hybrid nanomaterials
Sugawara A; Yamane S; Akiyoshi K
Macromol. Rapid Commun, 27, 441 - 446, 2006

[9] Synthesis and characterization of amphiphilic polyphosphates with hydrophobic graft chains and cholesteryl groups as nanocarriers
Iwasaki Y; Akiyoshi K
Biomacromolecules, 7, 1433 - 1438, 2006

[8] Platelet separation from whole blood in an aqueous two-phase system with water-soluble polymers
Sumida E; Iwasaki Y; Akiyoshi K; Kasugai S
J. Pharmacol. Sci., 101, 91 - 97, 2006

[7] Dual mode bioreactions on polymer nanoparticles covered with phosphorylcholine group
Ito T; Watanabe J; Takai M; Konno T; Iwasaki Y; Ishihara K
Colloid Surf., B: Biointerfaces., 50, 55 - 60, 2006

[6] Stress response of adherent cells on a blend polymer surface composed of a segmented polyurethane and MPC copolymers
Sawada S; Iwasaki Y; Nakabayashi N; Ishihara K
J. Biomed. Mater. Res., 79A, 476 - 484, 2006

[5] Highly wettable polyethylene films generated by spontaneous surface enrichment of perfluoroalkylated phosphorylcholines
Iwasaki Y; Akiyoshi K
J. Appl. Polym. Sci., 102, 2868, 2006

[4] Heat shock protein-like activity of nanogel artificial chaperone for citrate synthase
Sawada S; Nomura Y; Aoyama Y; Akiyoshi K
J. Bioact. Compat. Polym., 21, 487 - 501, 2006

[3] A flexible and wearable glucose sensor based on functional polymers with Soft-MEMS techniques
Kudo H; Sawada T; Kazawa E; Yoshida H; Iwasaki Y; Mitsubayashi K
Biosens. Bioelectron, 22, 558, 2006

[2] Inhibition of the formation of amyloid beta-protein fibrils using biocompatible nanogels as artificial chaperones
Ikeda K; Okada T; Sawada S; Akiyoshi K; Matsuzaki K
FEBS Lett., 580, 6587, 2006

[1] HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan
Kitano S; Kageyama S; Nagata Y; Miyahara Y; Hiasa A; Naota H; Okumura S; Imai H; Shiraishi T; Masuya M; Nishikawa M; Sunamoto J; Akiyoshi K; Kanematsu T; Scott AM
Clin. Cancer Res., 12, 7397, 2006
Murphy R, Hoffman EW, Old LJ, Shiku H

2005

[13] Thermoresponsive controlled association of protein with a dynamic nanogel of hydrophobized polysaccharide and cyclodextrin: Heat shock protein-like activity of artificial molecular chaperone
Nomura Y; Sasaki Y; Takagi M; Narita T; Aoyama Y; Akiyoshi K
Biomacromolecules, 6, 447 - 452, 2005

[12] In situ modification on cellulose acetate hollow fiber membrane modified phospholipid polymer for biomedical application
Ye SH; Watanabe J; Iwasaki Y; Ishihara K
J. Membr. Sci., 249, 133 - 141, 2005

[11] Cell separation in microcanal coated with electrically charged phospholipid polymers
Ito T; Iwasaki Y; Narita T; Akiyoshi K; Ishihara K
Colloids Surf., B:Biointerface., 41, 175 - 180, 2005

[10] Design of functional hollow fiber membranes modified with phospholipid polymers for application in total hemopurification system
Ye SH; Watanabe J; Takai M; Iwasaki Y; Ishihara K
Biomaterials, 26, 5032 - 5041, 2005

[9] Phospholipid polymer surfaces yield reduced bacterial and leukocyte adhesion under dynamic flow conditions
Patel J; Iwasaki Y; Ishihara K; Anderson JM
J. Biomed. Mater. Res., 73A, 359 - 366, 2005

[8] Changes in the morphology of cell-size liposomes in the presence of cholesterol: Formation of neuron-like tubes and liposome networks
Nomura SM; Mizutani Y; Kurita K; Watanabe A; Akiyoshi K
Biochim. Biophys. Acta: Biomembranes., 1669, 164 - 169, 2005

[7] Selective cell attachment to a biomimetic polymer surface through the recognition of cell-surface tags
Iwasaki Y; Tabata E; Kurita K; Akiyoshi K
Bioconjugate Chem., 16, 567 - 575, 2005

[6] Nanogel-quantum dot hybrid nanoparticles for living cell imaging
Hasegawa U; Nomura SM; Kaul CS; Hirano T; Akiyoshi K
Biochem. Biophys. Res. Commun., 331, 917 - 921, 2005

[5] Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: Interaction with proteins and chaperone-like activity”
Morimoto N; Endo T; Iwasaki Y; Akiyoshi K
Biomacromolecules, 6, 1829 - 1834, 2005

[4] Hybrid nanogels with physical and chemical cross-linking structures as drug carrier
Morimoto N; Endo T; Ohtomi M; Iwasaki Y; Akiyoshi K
Macromol. Biosci., 5, 710 - 716, 2005

[3] Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds
Katakura O; Morimoto N; Iwasaki Y; Akiyoshi K; Kasugai S
J. Med. Dent. Sci., 52, 115 - 121, 2005

[2] Well-controlled nanobiointerface generated from phosphorylcholine block copolymers brushes via a “grafting from” process
Iwata R; Iwasaki Y; Akiyoshi K; Takahara A
Trans. Mater. Res. Soc. Jpn., 30, 735 - 738, 2005

[1] Segmented polyurethane modified by photopolymerization and cross-linking with 2-methacryloyloxyethyl phosphorylcholine polymer for blood-contacting surfaces of ventricular assist devices
Kobayashi K; Ohuchi K; Hoshi H; Morimoto N; Iwasaki Y; Takatani S
J. Artif. Organs., 8, 237 - 244, 2005

2004

[13] Polyethylene/phospholipid polymer alloy as an alternative to poly(vinylchloride)-based materials
Ishihara K; Nishiuchi D; Watanabe J; Iwasaki Y
Biomaterials, 25, 1115 - 1122, 2004

[12] Innovative gas injection technique for closed hollow obturator
Iramaneerat W; Seki F; Watanabe A; Mukohyama H; Iwasaki Y; Akiyoshi K; Taniguchi H
Int. J. Prothdont., 17, 345 - 349, 2004

[11] Improved wet bonding of methyl methyl methacrylate-tri-n-butylborane resin to dentin etched with ten percent phosphoric acid in the presence of ferric ions
Iwasaki Y; Toida T; Nakabayashi N
J. Biomed. Mater. Res., 68A, 566 - 572, 2004

[10] Novel biodegradable polyphosphate cross-linker for making biocompatible hydrogel
Iwasaki Y; Nakagawa C; Ohtomi M; Ishihara K; Akiyoshi K
Biomacromolecules, 5, 3, 1110 - 15, 2004

[9] Nano-scale surface modification of a segmented polyurethane with a phospholipid polymer
Morimoto N; Watanabe A; Iwasaki Y; Akiyoshi K; Ishihara K
Biomaterials, 25, 23, 5353 - 5361, 2004

[8] Photoresponsive Nanogels Formed by the Self-Assembly of Spiropyrane-Bearing Pullulan That Act as Artificial Molecular Chaperones
Hirakura T; Nomura Y; Aoyama Y; Akiyoshi K
Biomacromolecules, 5, 5, 1804 - 1809, 2004

[7] Single molecular mechanics of a cholesterol-bearing pullulan nanogel at the hydrophobic interfaces
ImShik Lee; Akiyoshi K
Biomaterials, 25, 2911 - 2918, 2004

[6] Efect of remaining demineralised dentine on dental microleakage accessed by a dye penetration: how to inhibit microleakage?
Piemjai M; Watanabe A; Iwasaki Y; Nakabayashi N
J. Dentistry., 32, 495 - 501, 2004

[5] Copolymers of 2-methacryloyloxyethyl phosphorylcholine (MPC) as biomaterials
Nakabayashi N; Iwasaki Y
Biomed. Mater. Eng., 14, 345 - 354, 2004

[4] Design of biodegradable amphiphilic polymers: Well-defined amphiphilic polyphosphates with hydrophilic graft chains via ATRP
Iwasaki Y; Akiyoshi K
Macromolecules, 37, 7637 - 7642, 2004

[3] Control of nano-biointerfaces generated from well-defined biomimetic polymer brushes for protein and cell manipulations
Iwata R; Suk-in P; Hoven VP; Takahara A; Akiyoshi K; Iwasaki Y
Biomacromolecules, 5, 2308 - 2314, 2004

[2] Calcium Carbonate/Polymer Composites: Polymorph Control for Aragonite
Sugawara A; Kato T
Composite Interf., 11, 287 - 295, 2004

[1] Water-soluble phospholipid polymer as a new biocompatible synthetic DNA carrier
Sakaki S; Tsuchida M; Iwasaki Y; Ishihara K
Bull. Chem. Soc. Jpn., 77, 2283 - 2288, 2004

総説

著書

受賞

2013.7.31

第23回バイオ・高分子シンポジウム　学生優秀ポスター賞

『両親媒性グルカンデンドリマーの設計と人工分子シャペロン機能』

○竹田 茂生・高橋 治子・久保 亜希子・澤田 晋一・秋吉 一成

2014.5.30

第63回高分子学会年次大会　高分子学会優秀ポスター賞

『脂質膜被覆無機ハイブリッド微粒子の設計と機能』

○竹谷以紀・シクラ 駿・秋山 源・澤田 晋一・佐々木 善浩・秋吉 一成

2014.7.31

第30回日本DDS学会 永井賞

『ナノゲル工学の提唱と新規DDSの開発』

○秋吉 一成

2014.9.26

第63回高分子討論会　高分子学会優秀ポスター賞

『マイクロチャネル法によるナノゲルー光架橋微粒子の設計と機能』

○津田 将志・田原 義朗・佐々木 義浩・澤田晋一・秋吉 一成

『多分岐ガラクトキシログルカンナノゲルの設計と機能』

○湯川 寛子・竹田 茂生・澤田 晋一・佐々木 善浩・秋吉 一成

2014.11.18

第36回日本バイオマテリアル学会大会　　ハイライト講演

『無機微粒子テンプレート法による新規バイオマテリアルの開発』

○佐々木 善浩・竹谷 以紀・シクラ 駿・澤田 晋一・秋吉 一成

2015.5.29

第64回高分子学会年次大会　高分子学会優秀ポスター賞

『抗原デリバリーシステムとしての多糖ナノゲルの機能評価』

○犬塚 佑希浩・田原 義朗・向井 貞篤・澤田 晋一・佐々木 善浩・秋吉 一成

『多糖ナノボールの集積制御に基づく新規ゲル材料の設計とバイオマテリアル応用』

○沖田 圭司・竹田 茂生・橋本 良秀・向井 貞篤・澤田 晋一・佐々木 善浩・秋吉 一成 

『生体膜ナノチューブ固定化ヒドロゲルの設計とバイオ機能』

○吉竹 広記・澤田 晋一・佐々木 善浩・秋吉 一成

『ビタミンB6置換ポリマーによる酵素ハイブリッドの設計と機能』

○吉村 貴大・西村 智貴・澤田 晋一・佐々木 善浩・秋吉 一成

2015.7.17

第61回高分子研究発表会　エクセレントポスター賞

『微粒子泳動法によるナノゲル集積チューブの設計と機能』

○小齊 拓人・吉竹 広記・澤田 晋一・佐々木 善浩・秋吉 一成

2015.9.17

第64回高分子討論会　　高分子学会優秀ポスター賞

『人工細胞法による新規イムノリポソームの設計と機能』

○三浦 理紗子・安藤 満・澤田 晋一・向井 貞篤・佐々木 善浩・秋吉 一成

2016. 4. 13

The Chemical Society of Japan  CSJ Student Presentation Award 2016

“Control of protein refolding by amphiphilic glucan dendrimers”

D3  TAKEDA, Shigeo

2016. 5. 27 

第65回高分子学会年次大会　高分子学会優秀ポスター賞

『バイオ医薬品デリバリーのためのナノハイブリッドキャリアの設計と機能』

○河崎 陸・佐々木 善浩・片桐 清文・澤田 晋一・秋吉 一成

『機能性グルカンデンドリマーを用いた核酸デリバリー』

○竹田 茂生・澤田 晋一・佐々木 善浩・秋吉 一成

『酵素重合法を用いた多分岐糖鎖ナノゲルの合成と機能』

○山田 安乙奈・西村 智貴・澤田 晋一・佐々木 善浩・秋吉 一成

2016. 7. 28

第26回バイオ・高分子シンポジウム　学生優秀ポスター賞

『磁性ナノゲルキャリアによる細胞内タンパク質導入』
D3  河崎 陸

2016. 9. 16

第65回高分子討論会　高分子学会優秀ポスター賞

『生体内分離性を有するイオンナノゲル集積ゲルの設計と機能』
M1  児嶋 大世

2016. 12

IPC 2016 The 11th SPSJ International Polymer Conference　
BEST POSTER AWARD (Bioconjugate Chemistry)
D3  河崎 陸

2017. 5. 31

第66回高分子学会年次大会　高分子学会優秀ポスター賞

『音響波によるマイクロゲル構造の制御』
M1  角田 千里

2017. 7. 7

第33回日本DDS学界学術集会　優秀発表賞

『分岐多糖ナノゲルによる新規がんワクチンの開発』
D1　三浦 理紗子

『バキュロウイルス発現系を用いた機能性膜タンパク質発現細胞外ベシクルの設計と機能』
M2　石川 良賀

『機能性グルカンナノスフェアによるsiRNAデリバリーシステムの開発』
M2　張 若詩

2017. 9. 7

KIPS2017 International Symposium Excellent Poster Award (Bronze)

“Development of Antigen Delivery System by Self-assembled Branched Dextrin Nanogel”
D1  Risako Miura

2017. 9. 22

第66回高分子討論会　高分子学会優秀ポスター賞

『重圧印加法による細胞外ベシクルの放出誘導とバイオ機能評価』
M1　天野 愛

『膜タンパク質固相合成のための脂質膜コート微粒子の開発』
M1　氏平 勇樹

2017.11.22

第39回日本バイオマテリアル学会大会　優秀研究ポスター賞

『バキュロウイルス発現系による機能性膜タンパク質提示細胞外ベシクルの構築と機能』
○石川 良賀・吉田 昭介・澤田 晋一・佐々木 善浩・秋吉 一成